Associate Director/Director, Oncology Early Translation, Oncology Precision & Translational Medicine

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Job Description

About the role:

The Oncology Early Translation Associate Director (AD)/Director of Immunology will be a member of the Precision and Translational Medicine department within the Oncology Therapeutic Area Unit with the objective of developing and supporting oncology translational strategy as a senior member of the early translational oncology (eTO) team. The role bridges the discovery and clinical development organization and aims at supporting projects at the interface between discovery and early clinical development. The role will focus on providing Immunology insight and overseeing strategy of Cell Engager, Cell Therapy, and Cold-to-Hot discovery programs. Level will depend on the experience of the candidate.

How you will contribute:

ACCOUNTABILITIES

• The AD/Director of Immunology and Translational Research Lead (TRL) will join the Early Translational Oncology group as a scientific team lead and join early oncology programs to drive translational strategy from preclinical development through candidate selection and contribute to translational strategies in early clinical development through early Proof of Concept (ePOC).

• As a team lead, the Immunology lead/TRL will
  • Manage and mentor junior early translational team members across oncology programs.
  • Work with the other eTO leaders to drive and synergize translational strategies across early programs.
  • Partner with scientific leaders in Redirected Immunity (Cell Engagers and Cell Therapy) and Cold-to-Hot programs to develop and deliver translational strategies for discovery programs.
• Working with partners in preclinical stage project teams, the TRL will
  • Generate clear, testable translational hypothesis to address unmet needs (mechanism of action, pharmacodynamics, patient selection)
  • Partner with the project team lead to build the differentiation strategy for the therapeutic as well as defining the clinical and mechanism of action hypothesis and disease indication selection for early clinical development.
  • Define strategy for query of patient datasets to support translational hypothesis generation.
  • Contribute to hypothesis-driven study design, execution, and data analysis, including identification of most relevant preclinical and ex vivo models.
• Establish stage-appropriate project translational strategy for a differentiated asset to address unmet patient need with key Go/No Go decision points.
• Contribute to authoring and review of internal governance stage-gate documents.
• Design and manage external collaborations.
• Develop and contribute to scientific publications (conference abstracts and manuscripts)
• Working with partners in the clinical stage global project teams, the TRL will
• Design non-clinical experiments to support biomarker strategy, combination strategy as well as overall MOA-related translational questions.
• Contribute to the clinical translational team and work with the global translational lead to support answering specific translational questions.
• Contribute to the analysis and interpretation of clinical biomarker results, evaluation of translational hypothesis based on clinical data, and data-driven generation of new hypotheses with focus on reverse translation.
• Within the Translational Oncology function, the TRL will work closely with team representatives from the Computational Oncology and Integrated Translational Technologies groups to leverage patient datasets, patient samples, and diverse methodologies to support the translational strategy.

Minimum Requirements/Qualifications:

• PhD degree in immunology or cell biology with 10+ years’ experience and a minimum of 6+ years on the pharmaceutical or industry setting.
• Project team leadership or a translational team member role in an industry setting for assets progressing through IND-enabling studies and/or Phase I/II trials.
• Experience managing, mentoring, and developing direct reports.
• Superior knowledge and solid understanding of emerging research in Cell Therapies/Cell Engager/Immuno-oncology preclinically and clinically.
• Knowledge of the clinical landscape in solid tumors with good understanding of novel agents and impact to this landscape.
• Excellent oral and written communication skills, including writing, reviewing, and editing scientific documents.
• Superior interpersonal skills, diplomacy, and positive-influencing abilities.
• Ability to work and drive decision-making within a multi-disciplinary, multi-regional, matrix teams.
• Right attitude (agile, curious, open-minded, “can-do” mindset).
• Effective project management skills.
• Independent management of workload and expectations.
• Scientifically independent.
• Enterprise mindset.

Preferred experience/background

• Experience in clinical sciences including contribution to clinical trials or to observational clinical studies in an academic or industry setting.
• Track record of success and measurable contribution in moving oncology therapeutic programs forward through preclinical and/or clinical development in an academic or industry setting.
• Experience in research and/or development of immuno-oncology therapies.

What Takeda can offer you:

• Comprehensive Healthcare: Medical, Dental, and Vision
• Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
• Health & Wellness programs including onsite flu shots and health screenings
• Generous time off for vacation and the option to purchase additional vacation days
• Community Outreach Programs and company match of charitable contributions
• Family Planning Support
• Flexible Work Paths
• Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Base Salary Range: $143,500.00 to $205,000.00, based on candidate professional experience level. Employees may also be eligible for Short-term and Long-Term Incentive benefits as well. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off.

The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time