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Distinguished R&D Fellow, Immunology & Cell Therapy Innovation

応募後で応募 求人ID R0065393 掲載日 04/20/2022 Location:Boston, Massachusetts

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

OBJECTIVES: 

This is a dual discipline role. The candidate will lead efforts to optimize innate immunotherapies by overseeing gdT cell skin and blood cross-platform optimization through developing novel signaling and engineering approaches, as well as, have RMC sponsorship for broader enterprise exposure and contribution, achieving growing visibility in the organization and unlocking exciting development opportunities

ACCOUNTABILITIES: 

In capacity as Cell Therapy Innovation Leader:

  • Reports to the Head, Oncology Cell Therapy Innovation with management responsibility for a team of scientists in the Cell Therapy Innovation department
  • Leads efforts to optimize innate immunotherapies through developing novel signaling and engineering approaches to enhance cell functions based on the needs of specific diseases, including but not limited to, cell expansion, innate killing and differentiation between healthy and cancer cells
  • Lead Discovery work to achieve research PoC
  • Guide the non-clinical research work for achieving multiple milestones to IND
  • Follow these innovative new programs at least up to clinical proof-of-concept
  • Oversee gdT cell skin and blood cross-platform optimization and comparison to drive key decisions
  • Lead early-stage Discovery and exploratory work to build the foundation of next-generation cell therapies (examples such as: mixtures of NK and T cells, combinations of cell therapies and other modalities such as cell engagers or innate immune agonists, non-clinical model development for novel preconditioning, iPSC derived vd1 gdT cells, etc.) 
  • Participate in Takeda governance and decision-making forums such as Cell Therapy Council, PRC, and other senior leadership interfaces
  • Over time, select 1-2 clinical development teams in which to embed as an innate immunity effort helping guide overall strategy (can include programs outside cell therapies at any stage of development)
  • Serve on the Steering Committee for the MSKCC partnership; potential to take on additional JSC / Board roles over time
  • Co-lead Takeda's academic partnership with external leaders Adrian Hayday and Bruno De Santos Silva 
  • Serve as an advisor on Takeda's Cold-to-Hot Development Hub and / or Redirected Immunity Development Hub

In capacity as Distinguished R&D Fellow:

  • This role is sponsored at RMC level by the Head of the OTAU
  • Work with Head of R&D and Head of OTAU and other Senior Leaders to identify areas of broader enterprise exposure and contribution achieving professional growth, visibility, and impact in the broader Takeda organization to unlock impactful enterprise level development opportunities
  • Exposure to Takeda senior leaders through Fellow program
  • Contribute to innovative entrepreneurial models and business development (for example, venture investments, spin outs, etc.)
  • Contribute to Immunology strategies in other emerging areas of interest to Takeda (e.g. GI franchise)
  • Champion or contribute to a Takeda enterprise-level initiative
  • Gain exposure to global efforts, sites, and talents

Strategic Planning and Execution

  • Leads the innate immunotherapies strategies, goals, priorities and long-term plans and schedules. Aligns cross-functional, cross-divisional project goals with Takeda business needs and strategies.
  • Provides strategic, process, and operational leadership to the innate immunotherapies in the successful delivery of projects. Projects at this level will be of medium complexity and moderate project risk in disease areas with defined regulatory paths across all phases of development.
  • Links division sub-teams, through Divisional leaders/project management functions to align activities and ensure transparency of all project/product-related activity
  • Supports TA Leaders and Sub-leaders to set the vision and direction for innate immunotherapies and prioritizes all aspects of projects
  • Reports on progress of projects, issues/plans, and critical path schedules to Head, Oncology Cell Therapy Innovation, TAU Head and Takeda executive management through internal or external reviews of programs or projects.
  • Visibly advocates and supports key business initiatives:  Evaluates new opportunities and provides overall support for feasibility studies

Fiscal Responsibility

  • Responsible for project operating budgets within the global program; monitor and control expenditures; manages variance between budgeted and actual expenditures of time, dollars, and personnel while meeting overall Takeda financial objectives.

Resource and Issue Management

  • Manages internal and external resources (people, information, technologies, time, and capital); allocates resources appropriately
  • Proactively identifies innate immunotherapies project issues before they arise and develops contingency plans; communicates project-related issues to senior executive management and manages issues to resolution.

Change Management

  • Proactively responds to the dynamics of a changing marketplace; directs adjustments in functional or cross-divisional plans in response to changes in strategic direction.
  • Contributes to the creation and maintenance of systems/databases for the purpose of tracking key performance indicators (KPIs), trending, learning, and improving decisions regarding program performance and continuance.

Matrix Team Management

  • Provides matrix management, strategic and tactical leadership to members who are responsible for leading the key deliverables or Divisional sub-teams within individual projects.

EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS: 

Education/Experience:

  • Advanced scientific degree (MD, or PhD, or PharmD) in Immunology, Cell Biology)
  • Experience with and knowledge of Gamma Delta cells strongly preferred
  • Extensive experience and expertise in techniques such as cell culture, flow Cytometry, cytotoxicity assays, cell-based functional assays and immunoassays
  • Experience with IP and patent filing
  • Extensive experience in the pharmaceutical industry, with working knowledge of research and development and commercial operations
  • Experience with interdisciplinary global experience with complex projects including strategy and execution and matrix team management
  • Experience with matrix team management in a global environment

Preferred:

  • Advanced degree in science or business is desired
  • Broad business/enterprise orientation is highly preferred
  • Managed multiple NME global approvals

Knowledge and Skills:

  • Multi-faceted background with direct involvement or experience working with functions from multiple divisions: Research, Development, CMCC, Commercial/Marketing, Global Licensing and Business Development (GLBD)
  • Expert knowledge in the overall pharmaceutical drug development process, from discovery through post-marketing
  • Demonstrated ability to build consensus and drive resolution of issues while maintaining positive working relationships across functions, negotiation and strong persuasive abilities
  • Strong written and verbal Communication Skills:  ability to express oneself clearly and concisely to external partners, vendors or with others within the team; ability to message key issues appropriately and document issues and/or concerns concisely and comprehensively; ability to adjust language and/or terminology appropriate for the audience; Demonstrated ability to clearly and concisely communicate/present key information to senior management
  • Analytical and Problem-Solving Skills: ability to identify the critical issues of problems or opportunities using appropriate information; determines the causes and possible solutions to the problem
  • Leadership Skills: develops and uses knowledge and interpersonal skills to influence and guide others towards the accomplishment of Takeda’s goals and objectives.  Requires the flexibility and tolerance to best manage change and differing opinions with diplomacy and competence
  • Ability to drive decision-making within a cross-functional, cross-divisional and cross-cultural, global team structure and requires global mindset and cultural awareness in working with senior leadership in other regions and in managing cross-regional projects
  • Knowledgeable in the processes for managing and developing personnel in a cross-functional, matrix-team, global environment with a proven track record
  • Knowledgeable in budget and finance processes appropriate to the pharmaceutical industry
  • Ability to adapt to other personalities in a respectful manner that is conducive to goal achievement
  • Ability to capture knowledge within the cross-functional, cross-divisional global organization; improve solutions, processes, and deliverables through use of information; improve information capital by contributing experience, theories, deliverables, and models for others to use
  • Management of multiple tasks of varied complexity simultaneously
  • Ability to work in a stressful and demanding environment with aggressive project timelines

TRAVEL REQUIREMENTS:

  • Willingness to travel to various meetings or client sites, including overnight trips. Some international travel may be required.
  • Requires approximately 20-25% travel.

WHAT TAKEDA CAN OFFER YOU:

  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time
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