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Quantitative Pharmacologist, Cell Therapy Clinical Pharmacology and Modeling

応募後で応募 求人ID R0066184 掲載日 04/29/2022 Location:Boston, Massachusetts

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Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as a Quantitative Pharmacologist, Cell Therapy Clinical Pharmacology and Modeling where you will develop and implement mechanistic mathematical models of novel cell therapies, specifically their interactions with tumor cells and the patient's immune system. You will collaborate with preclinical, translational medicine, statistics, manufacturing and clinical research to develop mathematical models to understand targeted biological pathways and intracellular interactions of novel therapeutic modalities. All efforts will be directed toward progression of cell therapies into and through clinical development with the ultimate objective of global regulatory approval. Essential qualifications include in-depth understanding of cell biology ─ particularly in immunology and oncology ─ and numerical methods, as well as hands-on experience with modeling software, ability to clearly present modeling and simulation findings, and demonstrate ability to thrive in a matrix environment working at the leading edge of technologies.

How you will contribute:

  • Develop multi-scale quantitative systems pharmacology models to address project questions and provide scenarios to the project team to guide decision making e.g. influence combination strategies, optimize dose and schedules, biomarker identification and efficacy/toxicity predictions.

  • Conduct extensive literature review to identify suitable mechanistic elements, interactions, rate constants and sub-modules for incorporation into systems (disease) models

  • Identify areas and questions where advanced modeling may add value and work with collaborators to ensure right approach and tools are used.

  • Partner with key stakeholders in discovery, translational medicine, clinical development and clinical pharmacology to facilitate model development and application.

  • Stay abreast with emerging literature and science in the systems biology/pharmacology modeling and simulation sciences.

  • Build and maintain a personal track record of publication in the area of QSP.

  • Participate in writing publications and making scientific presentations consistent with development strategies and publication plan

Minimum Requirements/Qualifications:

  • Ph.D/Pharm.D/M.D with training in chemical or biomedical engineering, immunology, pharmaceutical sciences, mathematics, statistics, or equivalent area

  • Scientist: 0+ years relevant industry experience

  • Sr. Scientist: 3+ years relevant industry experience

  • 0-5 years of industry and academic experience in mathematical modeling of biological systems. Job title is flexible based on experience.

  • Strong competency in coding and running modeling and simulation related software such as Matlab, MONOLIX and R is required.

  • Publication(s) applying modeling and simulation approaches to oncology, immunology, cell biology and cancer biology is preferred.

  • Proficiency with systems modeling approaches such as ordinary and/or stochastic differential equations, Boolean, agent-based, or other advanced mechanistic modeling approaches is essential.

  • Good understanding of cell biology, physiology, and key concepts in pharmacometrics.

What Takeda can offer you:

  • Comprehensive Healthcare: Medical, Dental, and Vision

  • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs and company match of charitable contributions

  • Family Planning Support

  • Flexible Work Paths

  • Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Absent an approved religious or medical reason, all US field-based employees must be fully vaccinated for COVID-19, as a condition of employment.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time
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