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Quantitative Systems Pharmacology (QSP) Modeler

応募後で応募 求人ID R0064887 掲載日 04/25/2022 Location:Boston, Massachusetts

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Job Description

Quantitative Systems Pharmacology (QSP) Modeler

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as Quantitative Systems Pharmacology (QSP) Modeler in our Cambridge, MA.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

As a Quantitative Systems Pharmacology (QSP) Modeler working on the Modeling and Simulation team, you will be empowered to support global drug development by building models for rare diseases including lysosomal storage diseases, rare immunological diseases and hematology diseases.


  • Work on drug safety related modeling such as cardiac ion channel inhibition, myelosuppression, gastrointestinal toxicity, cytokine release syndrome and drug induced liver injury models.
  • Collaborate with clinical pharmacology, clinical research, nonclinical drug safety, drug discovery, drug metabolism, translational medicine and pharmacovigilance to develop mathematical models to understand the targeted biological pathways and exposure-response/safety relationship of novel therapeutic agents.
  • Responsible for implementing the right modeling & simulation strategy to assist with drug development, establish PK/PD relationships and create mechanistic pharmacology/toxicology models to support project needs.


  • Interface between clinical pharmacology, clinical research, nonclinical drug safety, drug discovery, drug metabolism, translational medicine and pharmacovigilance to influence drug development.
  • Work with cross-disciplinary teams, evaluating complex information to identify key scientific questions related to projects.
  • Design and build translational PK/PD and mechanistic models or platforms to assist with safety margin selection, study design and biomarker selection.
  • Communicate actionable output of modelling work to audiences in cross-disciplinary teams.
  • Present work at conferences, internal meetings, etc.


  • Ph.D/Pharm.D/M.D with training in mathematical modeling of biological systems. Suitable backgrounds include (but are not limited to) chemical or biomedical engineering, pharmaceutical sciences, physics, mathematics, statistics.
  • Must have 1+ years of industry experience. Job title is flexible based on experience.
  • Strong competency in coding and running modeling and simulation related software such as Matlab, NONMEM, Phoenix Winnonlin and R is required.
  • Proficiency with systems modeling approaches such as differential equation, logic, stochastic, agent-based, or other advanced mechanistic modeling approaches is essential.
  • Must enjoy learning novel biology and technologies, as well as working in inter-disciplinary environment.
  • Ability to prioritize and manage multiple projects while meeting project deadlines.
  • Publication(s) applying modeling and simulation approaches to rare diseases, hematology, and immunology preferred

Takeda U.S. Vaccine Requirement:

Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.


  • Minimal travel required


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

Empowering Our People to Shine

Discover more at

No Phone Calls or Recruiters Please.


EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


Boston, MA

Worker Type


Worker Sub-Type


Time Type

Full time