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Scientist I: In Vivo Pharmacologist

応募後で応募 求人ID R0067849 掲載日 05/19/2022 Location:Boston, Massachusetts

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Job Description

About the role:

Our vision is to be a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients.

Join Takeda as a Scientist I: In Vivo Pharmacologist where you will be responsible for the discovery and development of novel therapeutics in the cell engager space supporting new and ongoing pipeline programs using the COBRA platform. You will work with the PTL and manage critical in vivo path activities. You will also be responsible for new in vivo model development, target validation, assessing therapeutic concepts of different immune engager molecules, and advancing development candidates to IND. As part of the, you will report to Johara Chouitar, Senior Scientist Cell Engager Therapies IO Biology and In Vivo Lead

How you will contribute:

  • Develop animal models to test the biological efficacy of therapeutic agents for oncology indications
  • Execute in vivo efficacy models in xenograft and PDX models
  • Participate in analysis of in vivo studies to help establish PK / PD / efficacy relationships.
  • Demonstrate in-depth technical in vivo knowledge
  • Clarify requests and provide suggestions and put data into context especially in context of study design and quality of data
  • Serve as the in vivo lead on projects providing important scientific feedback to advance programs in a matrixed environment.
  • Help with external collaborations with CROs

Minimum Requirements/Qualifications:

  • MS with 6+ years experience or BS with 8+ years experience
  • Proficiency with in vivo efficacy rodent models, including mouse syngeneic, xenograft and PDX models
  • Experimental skills, including mammalian tissue culture, in vivo model development, drug administration by multiple routes (IV, SQ, IP, PO, RO), and blood/tissue collection. Cell culturing and maintaining human tumor cell lines and primary human cells with best practices in tissue culture.
  • Hands –on experience with multi-color flow cytometry, ELISA, MSD and other standard cell based and non-cell based biochemical assays.
  • Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro, Office 365, FlowJo etc)

What Takeda can offer you:

  • Comprehensive Healthcare: Medical, Dental, and Vision
  • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs and company match of charitable contributions
  • Family Planning Support
  • Flexible Work Paths
  • Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Absent an approved religious or medical reason, all US field-based employees must be fully vaccinated for COVID-19, as a condition of employment.

This position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policy.

In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


Boston, MA

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Worker Sub-Type


Time Type

Full time