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Associate Director/Director, Toxicology - Chemical Biology

応募後で応募 求人ID R0020879 掲載日 06/23/2020 Location:Cambridge, Massachusetts

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Job Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as an Associate Director Toxicology, Computational Biology/Chemical Biology in our Cambridge, Massachusetts office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. You will be empowered to provide leadership and global functional expertise for projects across the

Takeda portfolio.


As an Associate Director/Director of Toxicology with an expertise in Computational Biology/Chemical Biology; Leadership with 8+ years of biopharmaceutical drug development experience to lead these efforts within Non-Clinical Drug Safety.  This global role will develop the strategy and lead the application of bioinformatic/computational biology approaches to drive asset development and progression, while limiting safety risks across the four main therapeutic areas in our pipeline.  Utilizing computational and chemical biology expertise for safety applications, the candidate will have the opportunity to make direct contributions to global drug discovery efforts by applying strategic, in silico and experimental approaches in computational biology, molecular biology, genomics, bioinformatics, and cheminformatics to predict, prevent, and problem solve toxicities across our portfolio.  The individual will develop hypotheses and solutions regarding toxicity within global safety assessment.  This position will work as part of project teams at the intersection of chemistry, biology, and safety sciences to enable new ways to treat serious diseases. The scientist in this role will work closely with chemists, biologists, and safety scientists to plan and execute experiments designed to identify, prevent and problem solve the toxicities of our agents in cells.  This role will include helping to set the strategic direction for chemical biology group as well as management of several scientists. The ideal candidate will have a background in chemical biology with a strong track record of external leadership and collaboration with biologists and chemists.

Key Responsibilities •

Develop strategy and implement application of computational biology, bioinformatics and chemical biology to safety assessment within a global pharmaceutical company. 

Lead, manage and mentor colleagues at the intersection of biology, chemistry, and safety sciences.

Partner with multidisciplinary and highly collaborative discovery teams to optimize & accelerate the development of novel drug candidates using advanced computational techniques and experimental hypotheses based on expertise in computational biology and chemical biology as applied to safety assessment.

Apply directed evolution, protein chemistry and oligo-design knowledge to improve safety and selectivity of lead therapeutics.

Develop hypotheses to understand ligand-receptor on target and off target interactions and safety-related SAR by assimilating and interpreting data using modeling and data-mining techniques.

Maintain and develop working knowledge of computational biology and chemistry methods and their use in therapeutic design and data analysis as applied to safety assessment within drug discovery.

Participate in external collaborations and consortia.

Education, Experience, Knowledge and Skills •

A Ph.D. in Chemistry, Biochemistry, Chemical Biology, Synthetic Biology, Molecular Biology, Protein Engineering or equivalent with 10+ years of biopharmaceutic experience with an applied understanding of protein or nucleic acid engineering or molecular evolution and experience in chemical computational biology, bioinformatics, pathway analysis

Strong data analysis skills and a demonstrated ability to integrate information from different sources with a strong scientific understanding of molecular biology, genomics, and biological pathways applied to generate testable hypotheses.

Strong project and time management skills with the ability to deliver results on multiple concurrent projects in a fast-paced entrepreneurial environment. 

Prior experience leading projects or a team is a plus. Demonstrated leadership ability, including mentorship and management experience.  Proven ability to work with diverse scientific methods and collaborate across disciplines.

Serve as a scientific expert in chemical biology by proactively evaluating new technologies in the field, being well versed with current literature and provide scientific knowledge and support to other team members.


  • Up to 20% travel, both domestic and internationally may be required.


  • 401(k) with company match and Annual Retirement Contribution Plan
  • Tuition reimbursement
  • Company match of charitable contributions
  • Health & Wellness programs including onsite flu shots and health screenings
  • Generous time off for vacation and the option to purchase additional vacation days
  • Community Outreach Programs

Empowering Our People to Shine

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Takeda is an EEO employer of minorities, women, disabled, protected veterans, and considers qualified applicants with criminal histories in accordance with applicable laws. For more information, visit

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Cambridge, MA

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Full time