Senior Scientist Toxicology応募後で応募 求人ID R0070861 掲載日 07/06/2022 Location:San Diego, California
About the role:
Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Senior Scientist Toxicology in the Drug Safety Research and Evaluation (DSRE) division of Preclinical and Translational Sciences at our San Diego, CA site.
Our ideal candidate will have a proven track record supporting either cross-functional Discovery or Development drug project teams. The candidate will have experience in investigative, discovery, or development toxicology. The candidate will be able to leverage their deep insights into cellular and pathway mechanisms, coupled with knowledge of toxicology to provide expert advice and direction to improve the safety and quality of therapeutics. Experience with various therapeutic modalities (i.e., small molecules, oligonucleotides, cell or gene therapies) is highly desirable.
- Serve as a project team representative on cross-functional teams and across Global Safety to provide safety support to early discovery and/or development teams for Gastrointestinal and Neuroscience therapy areas, but with the possibility of supporting the Oncology, Rare Genetic Disease, and Hematology therapy areas as needed.
- As a member of project teams, the candidate will interact and provide guidance to other functional areas (e.g., DMPK, Pharmacology, Medicinal and Process Chemistry, Regulatory Affairs, Pharmacovigilance, and Clinical groups) regarding the necessary types of studies and the impact of findings from nonclinical safety studies on project progression.
- The candidate will serve as a project team representative responsible for design, interpretation, reporting, and presentation of nonclinical safety studies/programs.
- The candidate must be scientifically independent, and will be responsible for presentations to internal committees and at external meetings, as well as collaborating with scientists across our global sites in Boston and Japan and on collaborative programs with partner companies.
- Career development opportunities exist to represent Takeda Drug Safety Research and Evaluation on internal and external scientific working groups and committees.
Join Takeda as a Senior Scientist, Toxicology, based in San Diego, CA.
How you will contribute:
- Will serve as project toxicologist, and work with study a study monitor, to oversee the design, interpretation and reporting of exploratory and GLP-compliant studies that run internally or are outsourced.
- Develop comprehensive target safety reviews with risk mitigation plan for early drug discovery project teams based on literature, bioinformatics, and other predictive tools.
- Apply state of the art in silico, in vitro, and in vivo de-risking strategies to aid in the selection and optimization of large and small molecule therapeutics, as well as new therapeutic modalities
- Must be able to effectively contextualize study plans/results for team decision making in support of asset characterization
- Ensures that assigned projects are progressed within project timelines and budgetary agreements
- Independently provides well-written reports and regulatory documents; communicates directly with internal review boards and externally, including global regulatory agencies
- Collaborates with other departments, and disciplines, acting as scientific authority within discipline to coordinate interdepartmental activities for successful completion of safety studies
- Provides safety expertise regarding in- and out-licensing of company assets and helps develop a strategy to mitigate potential safety liabilities
- The candidate will be responsible for presentations to internal committees and at external meetings as well as collaborating with scientists across our research sites in Japan and Cambridge, MA and on collaborative programs with partner companies.
- Knowledge of GLP Regulations
- PhD degree in a scientific discipline with 3+ years’ pharmaceutical experience, or Master's degree with 9+ years’ experience
- Experience as a nonclinical safety representative on investigative, discovery, or development project teams with an understanding of scientific partner lines outside of toxicology
- Experience in working with contract research organizations is desirable
- Excellent oral and written communication skills
- Candidate must be adaptable to a dynamic workflow and must be highly collaborative
Board certification in toxicology desired, but not required
Routine demands of an office-based environment
Ability/willingness to travel to meetings or client sites (domestic and international; approximately 5%)
What Takeda can offer you:
- Comprehensive Healthcare: Medical, Dental, and Vision
- Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
- Health & Wellness programs including onsite flu shots and health screenings
- Generous time off for vacation and the option to purchase additional vacation days
- Community Outreach Programs and company match of charitable contributions
- Family Planning Support
- Flexible Work Paths
- Tuition reimbursement
More about us:
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.