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Associate Scientist, Global Biologics

応募 後で応募 求人ID R0152846 掲載日 05/28/2025 Location:Boston, Massachusetts

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Job Description

OBJECTIVES/PURPOSE

Design and implementexperiments to screen for drugcandidates and to addressmechanisms-of-action of therapeuticmolecules. Performcomplexcell-basedfunctionalexperimentsindependently. Actas a subjectmatterexpert (SME) for drugdiscoveryin the Cell therapy and Immuno-Oncology/Immuno-Therapy. 

ACCOUNTABILITIES

  • Provide broad assay development support forearly-stage drug discovery projects in disease areas of theCell therapy 

  • Design, execute, and validate a variety of assays to understandmechanisms of action and characterizeCAR T

  • Collaborate with automation engineers to identify suitable approaches to utilize laboratory automation for the execution of variable cell-based assays.

  • CAR Tgeneration (transduction and expansion) and functional evaluation of CAR expression, phenotyping, cytokine detection and killing potency in vitro.

  • Spend ~ 85% of time in the laboratory to maintain and implementcellcell-basedassayplatform and performexperiments

  • Interface with project teams to meet timelines for project progression

  • Present research findings clearly and effectively at internal and external meetings

  • Troubleshoot complex problems in creative and effective ways

  • Ability to manage workflow to deliverqualityresults in a timelymanner

  • Troubleshoot complexproblems in creative and effective ways and activelyparticipates in innovation and/or optimization of establishedprocesses to ensuredata relavence and quality

  • Ability to make data-driveninfluences onproject decision-making

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

  • Master's degree in cellimmunology, protein/antibody science,and/or >3yearsequivalentrelevant work experience with strong knowledge of T/NK cellbiology, immuno-oncology, and cell therapy. Bachelor’s degree with >6 yearsrelevantexperience. 

  • Tissue culture, includingapplication of aseptic techniques for media compounding, passaging, maintenance, and cryopreservation of cellcultures.

  • Experience with immune cell (T/NK cells) isolation, culture, and engineering.

  • Proficiency in immune cellphenotyping (surface/intracellular), cytokinedetection (multi-color flow cytometry, Luminex, MSD), cytotoxicityassay (short or long termkilling), internalizationassay and High content imaging (Opera Phenix) or otherfunctionalassays.

  • Proficient in data generation (Prism, Excel), presentation, and troubleshooting.

  • Experience with viral delivery methodsis a plus.

  • Knowledgeable and experienced in cellbiology and antibodycharacterization

  • Experience in troubleshooting,assayoptimization and data quality controlis a plus

  • Skilled in data analysis, interpretation, and data reporting

  • Hands-oncell-basedfunctionalassayexperience

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$99,500.00 - $156,420.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
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