Engineer III, Process Safety

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Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Synthetic Molecule Process Development (SMPD) is responsible for developing robust, cost-effective processes for new small-molecule pharmaceuticals, including methods to achieve and control high standards of crystal form, particle size distribution, and product quality.

The successful candidate will take charge of cutting-edge process safety workflows and evaluations, ensuring that the latest technologies are leveraged at every stage of process research, development, and manufacturing. They will be responsible for reducing process risks and enabling a safer, smarter, and faster development Additionally, the Engineer III will help build and maintain SMPD’s process safety database while championing an in-silico first mindset to minimize experimentation and promote data-driven decisions.

Join Takeda as an Engineer III, Process safety.  As part of the SMPD - Process Engineering & Technology team, you will report to the Associate Director of Process Engineering.

How you will contribute:

• Support phase appropriate process safety testing.

• Work with process chemists and engineers to perform a thorough evaluation of all known and potential hazards for the safe scale-up of chemical processes for preparing pharmaceutical intermediates and active pharmaceutical ingredients in Takeda's research and manufacturing facilities.

• Collect and integrate relevant process safety data (e.g., calorimetry, pressure build-up, off-gassing), using for e.g. DSC, ARC, TSU, EasyMax, RC-1 and ARC into digital platforms for seamless data analysis and sharing, ensuring data complies with FAIR principles (Findable, Accessible, Interoperable, Reusable).

• Work with external vendors to collect relevant process safety data.

• Document and summarize safety results in an Electronic Lab Notebook (ELN) and generate comprehensive digital process safety reports, ensuring consistent and accessible data tracking and compliance documentation.Partner with internal & external manufacturing organizations to ensure the safe scale-up of Takeda's processes.

• Use software and build models to calculate critical process parameters, such as runaway reactions, self-accelerating decomposition temperature (SADT), and time to maximum rate under adiabatic conditions (TMRad), driving proactive safety interventions.

• Maintain SMPD's kilo labs, ensuring that they are safe, clean and functional.

• Manage the kilo lab inventory (including chemicals, reagents, equipment & consumables) and ensure adequate supplies are available.

• Coordinate with contractors, vendors, and internal stakeholders to oversee the installation, commissioning, and qualification of kilo lab equipment and systems.

• Oversee internal manufacturing campaigns (e.g. reviews batch records, set-up equipment, support execution & cleaning).

• Support local initiatives as directed by his/her supervisor and participate in global functional initiatives as appropriate.

Minimum Requirements/Qualifications:

• Bachelor’s degree in Chemical Engineering, Chemistry, Mechanical Engineering or related field with 2+ years relevant industry experience; chemical or pharmaceutical industry preferred.

• Master’s degree in Chemical Engineering, Chemistry, Mechanical Engineering or related field with 0+ years relevant industry experience; chemical or pharmaceutical industry preferred.

• Previous experience working in a lab setting preferred.

• Previous experience working in a pilot plant setting a plus.

• Previous experience in process safety in the pharmaceutical, agrochemical, fine chemical or related industry a plus.

• Experience using relevant process safety equipment (e.g. DSC, RC1, Easymax HFCal, ARC, Tsu) a plus.

• Previous experience with software packages for process safety prediction (e.g., AKTS, Aspen Plus, gPROMS) a plus, focusing on the prediction of thermal, chemical, and kinetic properties.

• Understanding of FAIR data principles (Findable, Accessible, Interoperable, Reusable) to drive efficient data management for safety modeling and analytics.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$86,500.00 - $135,960.00

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.